High Ratio of Synaptic Excitation to Synaptic Inhibition in Hilar Ectopic Granule
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چکیده
High Ratio of Synaptic Excitation to Synaptic Inhibition in Hilar Ectopic Granule 1 Cells of Pilocarpine-Treated Rats 2 3 Ren-Zhi Zhan, Olga Timofeeva, and J. Victor Nadler 4 Department of Pharmacology and Cancer Biology and Department of Neurobiology 5 Duke University Medical Center, Durham, North Carolina 27710 6 7 Running head: Synaptic Responses in Hilar Ectopic Granule Cells 8 9 Correspondence: J. Victor Nadler, Department of Pharmacology and Cancer Biology, Box 3813, 10 Duke University Medical Center, Durham, NC 27710. Telephone: (919) 684-5317. FAX: (919) 11 681-8609. E-mail: [email protected]. 12 13 Articles in PresS. J Neurophysiol (September 29, 2010). doi:10.1152/jn.00663.2010
منابع مشابه
High ratio of synaptic excitation to synaptic inhibition in hilar ectopic granule cells of pilocarpine-treated rats.
After experimental status epilepticus, many dentate granule cells born into the postseizure environment migrate aberrantly into the dentate hilus. Hilar ectopic granule cells (HEGCs) have also been found in persons with epilepsy. These cells exhibit a high rate of spontaneous activity, which may enhance seizure propagation. Electron microscopic studies indicated that HEGCs receive more recurren...
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